Naltrexone and bupropion are combined in a single medication called Contrave, primarily used for weight management in individuals who are overweight or obese. Naltrexone is an opioid receptor antagonist that helps reduce food cravings, while bupropion is an antidepressant that can also suppress appetite and increase energy expenditure. The combination of these medications is thought to work synergistically to help promote weight loss. Contrave is typically used alongside a reduced-calorie diet and increased physical activity to achieve and maintain weight loss goals. It should be used under medical supervision due to potential side effects and interactions with other medications.