Low-dose naltrexone (LDN) is an off-label use of the medication naltrexone, typically in doses ranging from 1.5 to 4.5 mg per day. LDN is believed to modulate the immune system and reduce inflammation, potentially providing relief for conditions such as autoimmune diseases, chronic pain, fibromyalgia, and certain types of cancer. It’s thought to work by briefly blocking opioid receptors, leading to increased production of endorphins and other beneficial effects. LDN is often used as an adjunct therapy and should be prescribed and monitored by a healthcare professional.